Note: Seretide 25 microgram/50 microgram strength is not appropriate for adults and children with severe asthma. Seretide 250 Evohaler is a combination of two medicines that opens the airways and makes it easier to breathe. In patients with asthma a lesser degree of systemic exposure to inhaled fluticasone propionate has been observed. The tablet should not be swallowed. i m suffering from breathing problem cough chest infame . Seretide 250 Evohaler is used for Severe Allergic Reaction, Allergic Disorders, Asthma etc. It allows continued monitoring of the benefit/risk balance of the medicinal product. COPD Adult 1 inhalation of 50/250-50/500 mcg bd. There are no obvious differences in the safety profile between salmeterol-FP and FP alone (8-week double-blind period); moreover, no new safety signals were identified with administration of salmeterol-FP in the 16-week open-label extension period. 1mg provides you with medical information which is curated, written and verified by experts, accurate and trustworthy. Indications . Reseptilääke SERETIDE EVOHALER 25/250 mikrog/annos inhalaatiosumute, suspensio 1 x 120 annosta. Qualitative and quantitative composition, 4.2 Posology and method of administration, 4.4 Special warnings and precautions for use, 4.5 Interaction with other medicinal products and other forms of interaction, 4.7 Effects on ability to drive and use machines, 6.6 Special precautions for disposal and other handling, 9. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Patients should be instructed in the proper use and care of their inhaler and spacer and their technique checked to ensure optimum delivery of the inhaled drug to the lungs. Symptoms of asthma include shortness of breath, wheezing, chest Home Delivery with COD Available In an interaction study in healthy subjects with intranasal fluticasone propionate, ritonavir (a highly potent cytochrome CYP3A4 inhibitor) 100 mg b.i.d. increased the fluticasone propionate plasma concentrations several hundred fold, resulting in markedly reduced serum cortisol concentrations. Once asthma symptoms are controlled, consideration may be given to gradually reducing the dose of Seretide. Anticholinergics. There is likely to be a similar risk of interaction with other potent CYP3A4 inhibitors (e.g. The counter will stop at 000 when all the recommended puffs have been used. The canister has a counter attached to it, which shows how many actuations of medicine are left. Limited human data suggests that the drug does not represent any significant risk to the baby. Patients should continue holding their breath for as long as is comfortable. Less than 5% of the dose is excreted in urine, mainly as metabolites. Reseptilääke SERETIDE EVOHALER 25/250 mikrog/annos inhalaatiosumute, suspensio 1 x 120 annosta. The devices are available in cardboard containers, which hold: 10 x 120 actuations Inhaler - hospital/pharmacy use only (for dispensing purposes). Physicians should remain vigilant for the possible development of pneumonia and other lower respiratory tract infections in patients with COPD as the clinical features of such infections and exacerbation frequently overlap. Patients should be asked to continue treatment but to seek medical advice if asthma symptoms remain uncontrolled or worsen after initiation on Seretide. This information is intended for use by health professionals. Your privacy is guaranteed. Potassium replacement should be considered. It is manufactured by GlaxoSmithKline. Paradoxical bronchospasm responds to a rapid-acting bronchodilator and should be treated straightaway. - patients already adequately controlled on both inhaled corticosteroid and long-acting β2 agonist. Adrenergics in combination with corticosteroids or other drugs, excl. Indications . b If the resulting upper 95% CI estimate for the relative risk was less than 2.675, then non-inferiority was concluded. Neither salmeterol xinafoate or fluticasone propionate have shown any potential for genetic toxicity. Patients should check inside and outside of the inhaler including the mouthpiece for the presence of loose objects. Seretide is steroid. Before using for the first time patients should remove the mouthpiece cover by gently squeezing the sides of the cover, shake the inhaler well, hold the inhaler between the fingers and thumb with their thumb on the base, below the mouthpiece and release puffs into the air until the counter reads 120 to make sure that it works. Uses Seretide Evohaler is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms: Frequencies are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1000 to <1/100), rare (≥1/10,000 to <1/1000) and not known (cannot be estimated from the available data). The results of this study suggest that Seretide 50/100 microgram bd may be considered as initial maintenance therapy in patients with moderate persistent asthma for whom rapid control of asthma is deemed essential (see section 4.2). To take a second inhalation, patients should keep the inhaler upright and wait about half a minute before repeating steps 3 to 7. SERETIDE Inhaler (with counter), 25 mcg/250 mcg, aerosol inhaler, metered dose. 100/50, 250/50, 500/50 • SERETIDE MDI: 50/25, 125/25, 250/25 SERETIDE is used to help with asthma and chronic obstructive pulmonary disease (COPD) in people who need regular treatment. There is no incidence of additional adverse events following concurrent administration of the two compounds. ARD Pharma - Offering GSK Pharma Seretide 250mg Evohaler at Rs 540/bottle in Nagpur, Maharashtra. When suggestions are available use up and down arrows to review and ENTER to select. Seretide is indicated in the regular treatment of asthma where use of a combination product (long- acting β2 agonist and inhaled corticosteroid) is appropriate: - patients not adequately controlled with inhaled corticosteroids and 'as needed' inhaled short-acting β2 agonist. Both hoarseness and incidence of mouth and throat candidiasis may be relieved by rinsing the mouth with water and/or brushing the teeth after using the product. To email a medicine you must sign up and log in. While you are breathing in from mouth, press down on the inhaler one time to release the medication and hold your breath for 10 seconds. The main pathway is metabolism to an inactive carboxylic acid metabolite, by the cytochrome P450 enzyme CYP3A4. Seretide 250 Evohaler is used to treat Asthma, Chronic obstructive pulmonary disorder (COPD). Visual disturbance may be reported with systemic and topical corticosteroid use. For pharmacokinetic purposes therefore each component can be considered separately. Refer to section 4.4: risk of adrenal suppression. QUALITATIVE AND QUANTITATIVE COMPOSITION SERETIDE Inhaler 25 mcg/50 mcg: Each single actuation provides salmeterol xinafoate equivalent to 25 micrograms of salmeterol … 3. However, the data about efficacy and safety of salmeterol-FP are insufficient to establish the benefit/risk balance of salmeterol-FP in children under 4 years old. The main part of the dose is excreted in faeces as metabolites and unchanged drug. This does not need emergency action as adrenal function is recovered in a few days, as verified by plasma cortisol measurements. Dispose of the unused medicine. Fluticasone propionate containing medications in asthma during pregnancy. As with all inhaled medication containing corticosteroids, Seretide should be administered with caution in patients with active or quiescent pulmonary tuberculosis and fungal, viral or other infections of the airway. Make sure it is not consumed by pets, children and other people. SERETIDE EVOHALER 25/250 mikrog/annos inhalaatiosumute, suspensio 1 x 120 annosta. Repeat until you have inhaled the number of puffs as suggested by the doctor.Afterwards, rinse your mouth thoroughly with water and spit it out. As Seretide contains salmeterol and fluticasone propionate, the type and severity of adverse reactions associated with each of the compounds may be expected. - Two inhalations of 25 micrograms salmeterol and 125 micrograms fluticasone propionate twice daily. Situations, which could potentially trigger acute adrenal crisis, include trauma, surgery, infection or any rapid reduction in dosage. Following co-administration, increased incidences of transposed umbilical artery and incomplete ossification of occipital bone were found in rats at doses associated with known glucocorticoid-induced abnormalities. Seretide 250 Evohaler 25 microgram/250 microgram/dose pressurised inhalation, suspension. The mean number of moderate to severe exacerbations per year was significantly reduced with Seretide as compared with treatment with salmeterol, FP and placebo (mean rate in the Seretide group 0.85 compared with 0.97 in the salmeterol group, 0.93 in the FP group and 1.13 in the placebo). Children <12 years old may have difficulties synchronising aerosol actuation with inspiration of breath. There are no data in humans. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for seretide 250 accuhaler. This makes it easier for air to get in and out. Studies have shown that salmeterol and fluticasone propionate, and their metabolites, are excreted into the milk of lactating rats. Dry mouth may occur as a side effect. Patients should continue to use the same make of spacer device as switching between spacer devices can result in changes in the dose delivered to the lungs (see section 4.4). hi i am PATIENT am pregnant (15 weeks) currently suffering from cough and cold and hyperthoriod, doctor suggest to take seritide accuhaler 250 mg and ptu 50 mg for cough and thyorid it is safe during pregnency. Reporting suspected adverse reactions after authorisation of the medicinal product is important. 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