Avoid these practices. Epclusa is contraindicated with … Some mixtures of medications can lead to serious and even fatal consequences. There are 3 disease interactions with Epclusa (sofosbuvir / velpatasvir): Major Potential Hazard, Moderate plausibility. It is intended to be used as follows: Alteration in dose or regimen may be recommended based on drug interaction studies or predicted interactions. No dosage adjustment is required for patients with mild, moderate or severe hepatic impairment (Child-Pugh Class A, B or C). Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID), prescribed for osteoarthritis, rheumatoid arthritis and gouty arthritis. This tool may not cover all possible drug interactions. Avoid combinations; the risk of the interaction outweighs the benefit. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Interaction Checker. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. Find everything you need to know about Epclusa (Sofosbuvir And Velpatasvir), including what it is used for, warnings, reviews, side effects, and interactions. Usually avoid combinations; use it only under special circumstances. ASTRAL-1: Double-blind, placebo-controlled trial in GT 1, 2, 4, 5, or 6 patients (N=740). Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Drug interactions of Epclusa include acid reducing agents that are commonly used to treat heartburn, indigestion, and GERD, such as antacids, histamine 2 receptor antagonists. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. Sofosbuvir and velpatasvir are substrates of drug transporters P-gp and BCRP while GS-331007 (the predominant circulating … For example, famotidine, and proton pump inhibitors (PPIs) because they may decrease the effectiveness of Epclusa treatment … Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Applies to: Renal Dysfunction. EPCLUSA can cause serious side effects, including: • Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. Generic Name: sofosbuvir / velpatasvir Medically reviewed by Drugs.com. Use WebMD’s Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Both of these medications belong to the class of medications called antivirals. We would like to show you a description here but the site won’t allow us. The following chart provides information regarding potentially significant drug interactions with Epclusa (the table is not all-inclusive). The likelihood of drug interactions increases as the number of drugs being taken increases. Notes for Consumers: Although an interaction is possible, these drugs can be used together with caution. morphine levels, risk of CNS and resp. No dosage adjustment is necessary for patients with mild or moderate renal impairment. The interaction may increase or decrease the effectiveness of the drugs or the side effects of the drugs. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Available for Android and iOS devices. Are you sure you want to clear the Interaction Checker… EPCLUSA can cause serious side effects, including: • Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. Learn more about Epclusa … Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Drug Interactions Checker; A study for a 63 year old woman who takes Claritin, Epclusa, Ambien, Anoro Ellipta, Humalog Mix 75/25, Neurontin, Bentyl, Dexilant, Metformin, Ibu, Lisinopril - from FDA reports. It is possible that side effects, such as a reduced number of red blood cells, may develop if these drugs … Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Access our free, comprehensive and user-friendly drug interaction charts Educational Videos. A series of mini-lectures on topics including pharmacology, hepatitis and drug-drug interactions Prescribing Resources. Although we attempt to provide accurate and up-to-date information, no … Highly clinically significant. Usually avoid combinations; use it only under special circumstances. Patients who were active injection drug users (use within 12 months), or those with a positive urine drug test at screening, were excluded from the ASTRAL pivotal trials. Drug Interaction Checker. Highly clinically significant. Expected: ↓ Velpatasvir. HBV reactivation has been reported during or after completion of HCV direct-acting antiviral therapy in HCV/HBV-coinfected patients who were not receiving HBV antiviral therapy; some cases resulted in fulminant hepatitis, hepatic failure, and death. There are 3 disease interactions with Epclusa (sofosbuvir / velpatasvir) which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Epclusa : - Store and dispense in original container - Store below 86 degrees F. ... drug-induced hepatic injury, complex drug interactions, overlapping toxicities); therefore, it is recommended to initiate a fully … Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Use of EPCLUSA with Inducers of P-gp and/or Moderate to Strong Inducers of CYP 5.4 Risks Associated with Ribavirin and EPCLUSA Combination Treatment 6 ADVERSE REACTIONS 6.1 Clinical Trials Experience 6.2 Postmarketing Experience 7 DRUG INTERACTIONS 7.1 Potential for Other Drugs to Affect EPCLUSA 7.2 Potential for EPCLUSA to Affect Other Drugs Applies to: Immunodeficiency, Infectious Hepatitis. sofosbuvir, Vosevi, Sovaldi, Mavyret, Harvoni, ribavirin. Etoricoxib Interaction with 583 drugs. Epclusa is contraindicated with phenobarbital and phenytoin (see section 4.3). Drug interaction overview. Minimally clinically significant. Carbamazepine (Induction of P-gp and CYPs) Interaction not studied. Avoid combinations; the risk of the interaction outweighs the benefit. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Anytime you take more than one medication, or even mix it with certain foods, beverages, or over-the-counter medicines, you are at risk of a drug interaction. Interactions with hepatitis B drugs Over the past few months, we have been working on a project to include full interactions with the hepatitis B drugs which has involved assessing and adding ~6700 new interactions. Drugs & Medications Epclusa BCRP, OATP1B1, and OATP1B3 Substrates/Enasidenib Interactions This information is generalized and not intended as specific medical advice. Most drug interactions are not serious, but because a few are, it is important to understand the possible outcome before you take your medications. Drugs affecting sofosbuvir/velpatasvir. EPCLUSA is a combination of two anti-viral drugs: sofosbuvir (previously approved for HCV treatment) and velpatasvir (new drug for HCV). Sofosbuvir is extensively metabolized in the liver. Patients with serologic evidence of current or prior HBV infection should be monitored for clinical and laboratory signs of hepatitis flare or HBV reactivation during HCV therapy and posttherapy follow-up; appropriate patient management for HBV infection should be started as clinically indicated. Sofosbuvir - velpatasvir is used alone or with ribavirin to treat chronic (long-term) hepatitis C virus (HCV) infection. Moderately clinically significant. Moderately clinically significant. rate, consider decr. Select one or more newsletters to continue. Ideally, you should try to upgrade your browser to the latest version in order to use our full featured interaction checker. A total of 111 drugs are known to interact with Summary: 9 females aged 63 (±5) who take the same drugs … Prior to the completion of this project, many of the interactions with the HBV drugs … We comply with the HONcode standard for trustworthy health information -. 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